EXPERT
Elie Abed
Endocrinology-Diabetes | Endocrinology, Diabetes & Metabolism
- Tulsa, Oklahoma
- Accepting new patients
Diabetes and Life Expectancy
After diabetes diagnosis, many type 1 and type 2 diabetics worry about their life expectancy. Death is never a pleasant subject but it's human nature to want to know 'how long...
Can type 2 diabetes be reversed?
My son was diagnosed with thyroid issues?
What could be the cause of diabetic neuropathy?
Is a thyroid function test painful?
What are the causes of diabetes?
Type 2 diabetes is characterized by insulin resistance and a progressive decline in pancreatic β cell insulin production. There is no autoimmune-mediated pancreatic β cell damage and most patients with type 2 diabetes do not need insulin during the initial stages of the disease.
Insulin resistance is a condition in which insulin is produced, but is not used properly: a given amount of insulin does not produce the expected result. In people who are obese it may be that the chronic inflammation associated with obesity affects the function of the insulin receptors on the cells in the liver, muscles, etc., decreases the number of insulin receptors, affects insulin signaling pathways, or inactivates insulin receptors (Allende-Vigo, 2010; Olatunbosun, 2011).
The progressive decline in pancreatic β cell function is due to decreased β cell mass caused by apoptosis (Butler, Janson, Bonner-Weir, Ritzel, Rizza, Butler, 2003); this may be a consequence of aging, genetic susceptibility, and insulin resistance itself (Unger, Parkin, 2010). The etiology of type 2 diabetes is complex and involved genetic and lifestyle factors.
Genetic factors: There are susceptibility genes that definitely play a role in the development of type 2 diabetes, but their contribution appears to be small. The effect of the known, common gene variants in creating a pre-disposition to type 2 diabetes is approximately 5%-10% (McCarthy, 2010), so unlike some inherited diseases, being homozygous for these susceptibility genes does not typically result in a case of type 2 diabetes unless certain environmental (in this case lifestyle) factors are present.
Lifestyle factors/demographics: Obesity is definitely a major risk factor for the development of type 2 diabetes (Li, Zhao, Luan, et al, 2011), and the greater the degree of obesity, the higher the risk (Nguyen, Nguyen, Lane, Wang, 2011). Excess adipose tissue is typically in a state of chronic inflammation, and this inflammation is thought to cause insulin resistance in the adipose tissue and in other organs (Gutierrez, Puglisi, Hasty, 2009). Other factors that increase the risk of developing type 2 diabetes are the presence of the metabolic syndrome (Eckel, 2008), age, and a sedentary lifestyle. Type 2 diabetes is much more common in African-Americans than other ethnic groups. There may be a genetic explanation for this, but socio-economic factors are probably to blame (Link, McKinlay, 2009).
What tests should I take to see my thyroid levels?
Can type 2 diabetes cause a heart attack?
Can my hormone levels cause headaches?
How strict does my diet have to be with type 2 diabetes?
https://www.diabetes.org/nutrition/understanding-carbs/get-to-know-carbs
Can young people be diagnosed with diabetes?
Can kids be diagnosed with diabetes?
Is there more than one kind of insulin pump?
How do diabetics deal with low blood sugar?
The “rule of 15” is commonly used as a guideline for treatment: After checking your blood glucose level with your meter and seeing that your level is under 70 mg/dl, consume 15 grams of carbohydrate, wait about 15 minutes, then recheck your blood glucose level.
What symptoms should I look out for to have my thryroid checked?
How can I control my diabetes?
What is a thyroidectomy?
Is hypothyroidism hereditary?
What are the dangers of HGH?
It is contraindicated with patient who have history of brain cancer